The human intestines are constantly under the influence of numerous pathological factors: enteropathogenic microorganisms, food antigens, physico‐chemical stress associated with digestion and bacterial metabolism, therefore it must be provided with a system of protection against adverse impact. Recent studies have shown that Paneth cells play a crucial role in maintaining homeostasis of the small intestines. Paneth cells perform many vital functions aimed at maintaining a homeostatic balance between normal microbiota, infectious pathogens and the human body, regulate the qualitative composition and (...) number of intestinal microorganisms, prevent the introduction of potentially pathogenic species, and protect stem cells from damage. Paneth cells take part in adaptive and protective‐inflammatory reactions. Paneth cells maintain dynamic balance between microbial populations, and the macroorganism, preventing the development of intestinal infections and cancer. They play a crucial role in gastrointestinal homeostasis and may be key factors in the etiopathological progression of intestinal diseases. (shrink)

Unfounded—conspiracy and health—beliefs about COVID-19 have accompanied the pandemic worldwide. Here, we examined cross-nationally the structure and correlates of these beliefs with an 8-item scale, using a multigroup confirmatory factor analysis. We obtained a two-factor model of unfounded (conspiracy and health) beliefs with good internal structure (average CFI = 0.98, RMSEA = 0.05, SRMR = 0.04), but a high correlation between the two factors (average latent factor correlation = 0.57). This model was replicable across 50 countries (total N = 13,579), (...) as evidenced by metric invariance between countries (CFI = 0.96, RMSEA = 0.06, SRMS = 0.07) as well as scalar invariance across genders (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03) and educational levels (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03). Also, lower levels of education, more fear of COVID-19, and more cynicism were weakly associated with stronger conspiracy and health beliefs. The study contributes to knowledge about the structure of unfounded beliefs, and reveals the potential relevance of affective (i.e., fear of COVID-19) and cognitive (i.e., cynicism) factors along with demographics, in endorsing such beliefs. In summary, we obtained cross-cultural evidence for the distinctiveness of unfounded conspiracy and health beliefs about COVID-19 in terms of their structure and correlates. (shrink)

A lo largo de las siguientes páginas repasaremos el uso de la forma prosaica por parte de los sofistas y socráticos, viendo la influencia y relación entre ambos tipos de escritura. A este respecto, analizaremos los escritos sofísticos antinómicos resultantes de prácticas erísticas, ejemplificados por los llamados Dissoi Logoi. Consideraremos a continuación la influencia de este escrito sobre los Logoi Sokratikoi, desarrollados por los círculos de seguidores de Sócrates, buscando ver la correlación en la metodología y forma argumentativa, así como (...) también en el contenido, de ambos escritos, considerados tradicionalmente como representantes de posturas totalmente contrapuestas. Pretendemos, por tanto, resaltar la continuidad entre la corriente sofística y la socrática frente a la usual consideración de ambos grupos como enemigos intelectuales. (shrink)

A number of studies have shown that phonetic peculiarities, especially at the coarticulation level, exist in the disfluent as well as in the perceptively fluent speech of people who stutter (PWS). However, results from fluent speech are very disparate and not easily interpretable. Are the coarticulatory features observed in fluent speech of PWS a manifestation of the disorder, or rather a compensation for the disorder itself? The purpose of the present study is to investigate the coarticulatory behavior in the fluent (...) speech of PWS in the attempt to answer the question on its symptomatic or adaptive nature. In order to achieve this, we have studied the speech of 21 adult PWS (10 French and 11 Italian) compared to that of 20 fluent adults (10 French and 10 Italian). The participants had to repeat simple CV syllables in short carrier sentences, where C = /b, d, g/ and V = /a, i, u/. Crucially, this repetition task was performed in order to compare fluent speech coarticulation of PWS to that of PWNS, and to compare the coarticulation of PWS under a condition with normal auditory feedback (NAF) and under a fluency-enhancing condition due to an altered auditory feedback (AAF). This is the first study, to our knowledge, to investigate the coarticulation behavior under AAF. The degree of coarticulation was measured by means of the Locus Equations (LE). The coarticulation degree observed in fluent PWS speech is lower than that of the PWNS, and, more importantly, in AAF condition, PWS coarticulation appears even weaker than in the NAF condition. The results allow to interpret the lower degree of coarticulation found in fluent speech of PWS under NAF condition as a compensation for the disorder, based on the fact that PWS’s coarticulation is weakening in fluency-enhancing conditions, further away from the degree of coarticulation observed in PWNS. Since a lower degree of coarticulation is associated to a greater separation between the places of articulation of the consonant and the vowel, these results are compatible with the hypothesis that larger articulatory movements could be responsible for the stabilization of the PWS speech motor system, increasing the kinesthetic feedback from the effector system. This interpretation shares with a number of relatively recent proposal the idea that stuttering derives from an impaired feedforward (open-loop) control system, which makes PWS rely more heavily on a feedback-based (closed loop) motor control strategy. (shrink)

The paper addresses the use of heterogeneous ensembles of intelligent unmanned vehicles in such a perspective field of innovations as an unmanned fishery. The issues of joint activity of unmanned vehicles of different types in fishing operations based on intelligent technologies are investigated. The “smart fishing” approach based on the joint fishing operation model is proposed. The operational framework that includes missions, roles, and activity scenarios embedded in the discretized spatial model is presented. The scenario activities are considered as the (...) sequences of pentad that determine executing specific functions concerning the specified waypoint, timepoints, and the states of vehicles. The definition of the plan as the scenario prototype that needs adjusting to the conditions of the situational context is proposed. The coordination problem regarding the joint activities of the unmanned vehicles and their scenarios is defined and the coordination framework based on the distributed common board model and coordination primitives is presented. The prototype of the intelligent scenario-based system including the implementation of both operational and coordination frameworks developed for the control of unmanned vehicles is described. This system makes unmanned vehicles capable to absorb all the latest advances in intelligent technologies to perform smart fishing operations jointly in a large heterogeneous group. The proposed approach to smart fishing using intelligent technologies makes it possible to detach fishermen from the fishing activities dangerous to their life and health, to reduce significantly poaching and illegal fishing, to increase the overall efficiency of fishing operations, and even to save the marine ecosystem. (shrink)

Extracellular nucleic acids are found in different biological fluids in the organism and in the environment: DNA is a ubiquitous component of the organic matter pool in the soil and in all marine and freshwater habitats. Data from recent studies strongly suggest that extracellular DNA and RNA play important biological roles in microbial communities and in higher organisms. DNA is an important component of bacterial biofilms and is involved in horizontal gene transfer. In recent years, the circulating extracellular nucleic (...) acids were shown to be associated with some diseases. Attempts are being made to develop noninvasive methods of early tumor diagnostics based on analysis of circulating DNA and RNA. Recent observations demonstrated the possibility of nucleic acids exchange between eukaryotic cells and extracellular space suggesting their participation in so far unidentified biological processes. BioEssays 29:654–667, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Crises such as water quality, pollution, climate change, overfishing, biodiversity, energy, waste, and carbon sequestration mean that legislation protecting the marine environment is under intense pressure to be effective and to demonstrate positive results in a vast array of public and private spheres. Thus far, scholarship of EU marine environmental law has been focused primarily on (i) interaction with international agreements (ii) spatial/jurisdictional studies (iii) analysis of new laws, plans and programmes (iv) principles (e.g. good environmental status, precautionary (...) approach, polluter pays) (v) CJEU case analysis (vi) enforcement (vii) specific issues (plastics, litter…). However, over the years the mass constituted by the EU marine environment acquis has grown ever-larger, leading to risks of poor coordination, over-regulation in some areas and lack of regulation in others. By triangulating complementary investigatory methodologies, this study teases out systemic, diachronic and legilinguistic interlinkages—within and across key instruments as well as EU institutions, bodies and agencies. Our results provide avenues for policymakers nationally and at EU level to improve the legibility and coherence of marine environmental regulation—to the benefit of citizens and the wider body of stakeholders, and, ultimately, to benefit the marine world. (shrink)

t. 1. Vlastʹ kli︠u︡cheĭ -- t. 2. Na vesakh Iova.

Книга представляет собой исследование, где предпринимается попытка на основе детальной проработки первоисточников и воспроизведения основных ходов мысли и интуиций Гегеля и позднего Шеллинга провести сравнительный анализ их учений об абсолюте.

Издание представляет результаты исследования малоизученной темы социально-экономических доктрин консерватизма. Оно отражает их развитие от времени выражения их в виде утопий, погруженных в более общие социально-философские и политические учения.

In this paper the author focuses on Australian land management and in particular on the environmental management issues that could have been prompted by the High Court recognition in 1996 (in Wik Peoples v. The State of Queensland) that native title to land and pastoral leaseholdings can co‐exist. Drawing on themes of self‐determination and co‐existence, the paper looks at more specific topics such as aboriginal title to land—what has been called land rights or native title in Australia—and some implications of (...) that for land, sea and resource management. Central to this analysis are competing theories of Aboriginal land management and links between Aboriginal traditional knowledge and conservation of species. These are illustrated through the marine mammal, the dugong. The Australian debates lead to the Canadian debates and then to Scandinavia and the role of the Sami people in protection and management of the Arctic region. Issues of indigenous self determination inevitably provide an overall theme to these discussions. As a matter of global concern, the paper asks, but does not decide, whether indigenous peoples may manage fragile eco‐systems more effectively than outsiders. It maintains that what is important in this context is a broader question. This concerns how culturally inclusive land and resource management can emerge from recognition of indigenous land and human rights and how comparative developments can provide crucial cross‐jurisdictional information for future developments and opportunities in the interests of environmental conservation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:THEOLOGY AT FRIBOURG SINCE ITS FOUNDATION in 1889, the faculties of theology and of philosophy at the University of Fribourg in Switzerland have been under the auspices of the Dominican Order. Unlike the Catholic University at Lublin (Poland) where a consciously developed school of phenomenological Thomism exists, one can speak only in the broadest terms about a "Fribourg school" of philosophy or theology. The reason for this lies in (...) the fact that members of the Faculty have professionally proved themselves in varied and highly specialized areas of theology, in dogmatic and moral theorology, in exegesis, canon law, liturgy, etc. Historically this appraisal finds verification when one considers the contributions made in the first half of the century by such men as N. del Prado, F. Marin-Sola, and G. Manser in dogmatics; D. Prummer in morals; V. Zapletal and M. Sales in Scripture; and P. Mandonnet in historical theology.1 A similar list of distinguished philosophers and theologians who have taught in the more recent past or who are actually teaching at the University could be drawn up, although it would be too long to include here. The books chosen for discussion in this article have been recently published by three members of the Faculty of theology-two of whom are emeritus. Although they represent a small part of the present Faculty's scholarly output, they do provide, as the titles indicate, substantial samples of the full range of systematic theological inquiry in ethics and dogma. Nonetheless, the shared conception of theology which directs each author's approach to his respective discipline warrants joint consideration. 1 Information on the early period of the University may be found in J. Bondallaz, "Suisse" in the Dictionnaire de Theologique Oatholique, Vol. 14 (Paris, 1941) : Cols. 2733-2760. 325 326 ROMANUS CESSARIO, O.P. Broadly speaking, this shared conception derives from the strongly unified view of theology as sa.cra doctrina set forth by St. Thomas Aquinas at the very beginning of his Summa theologiae. By definition Christian theology results from intelligent reflection upon the revealed Word of God. As such it embraces within its range of concerns everything which has to do with God himself and the real world He created. Still, because of his capacity for an authentic relationship with the blessed Trinity and the special destiny implied in the status of adoptive sonship, the human person holds a privileged place among theology's interests. As a result, the starting point for theology is the words and deeds of Jesus Christ as they have been recorded in the canonical Scriptures. These acta et gesta Christi hold a unique place in the life of the Christian Church precisely because of who Jesus is, a man, one like us, hypostatically united to the divine Logos. For Aquinas theology finds its starting point in the very depths of God's Being where the Eternal Father speaks the personal Word which perfectly reflects the Godhead. In this St. Thomas reflects the clear Johannine teaching on the Trinitarian origins of all Christian life and thought, " Now they know that everything that thou hast given me is from thee; for I have given them the words thou gavest me...." (John 17 7,8). This shared conception of the nature and purpose of theology as well as the common site of their teaching careers unite the Dominican authors whose works are discussed here.2 I In his book, Theologia, which received much attention in theological educational circles, Edward Farley described a 2 Jean-Herve Nicolas, O.P., Synthese Dogmatique: De la Trinite ala Trinite (Fribourg [Suisse]: Editions Universitaires and Paris: Editions Beauchesne, 1985). Pp. xii+ 1248. FS 120,-. Servais (Th.) Pinckaers, O.P., Les sources de la morale chretienne. Sa methode, son contenu, son histoire. Etudes d'ethique chretienne, Vol. 14 (Fribourg [Suisse]: Editions Universitaries and Paris: Editions du Cerf, 1985). Pp. 523. FS 45.-. Ceslaus Spicq, O.P., Oonnaissance et Morale dans la Bible. Etudes d'ethique chretienne, Vol. 13 (Fribourg [Suisse]: Editions Universitaires and Paris: Editions du Cerf. 1985). Pp. 186. THEOLOGY AT FRIBOURG 327 process he called the fragmentation of theology.3 Arguing from within the Protestant experience, Farley points to certain historical circumstances which explain... (shrink)

Purpose. Based on the comparative analysis of the European and post-Soviet countries, the purpose of the article is to study one of the manifestations of gender discrimination, namely the problem of gender equality in the sphere of labor. It involves the consistent solution to the following tasks: a) to emphasize the basic principles of gender international and legal policy; b) to reflect the praxeological dimension of providing the equal social and economic opportunities for men and women at current level; c) (...) to emphasize the key criterion for ensuring the equality in socio-cultural sphere – equality in political life; d) to study the educational level of women and the possibility of self-realization in employment equal to men. Theoretical basis. The authors proceed from the standpoint that gender equality at the present stage has become a priority of legal policy and an important principle of the state of pro-European orientation. It is characterized in the legal plane, first of all, by the equality of the social roles of men and women, and the overcoming of the gender hierarchy of social ties, in which men are perceived as higher beings by their mental and physical abilities, and their activities are more significant and of priority in comparison with the activities of women. Originality. The authors have substantiated that in many economically developed countries the problem of providing a gender is still relevant, but most of the crisis problems in this area have found their legal regulation. The motivated position of the authors is that the level of education and professionalism of women cannot serve a reason for discrimination against women, which now exists in the economic and political sphere in the post-Soviet space. Conclusions. Gender stereotypes remain the priority in woman’s keeping family household, which creates significant inequalities of women and men at the labor market. Specialized regulatory acts in the field of gender declare the equality of men and women, while labor law defines a number of norms and guarantees that complicate the employment of women. In order to improve the situation we propose to implement a number of measures, such as, creation and financial support of the programs at the state level for supporting maternity, family and childhood; examination of all normative acts and concerning the issue of gender asymmetry, and especially the norms of labor law; introduction of state monitoring of employment and income of persons as to the complying with the principle of gender equality; introduction of quotas for women’s participation in political activities, in the work of the government and parliament, etc. (shrink)

Methodology and ethics: these two terms have only recently begun to be linked organically in scientific thought, especially when the discussion is about man as the subject and object of knowledge. It is not as if this situation had not been anticipated in the history of thought. Suffice it to mention Kant's perspicuity: his analysis of "the conditions of the thinkability" of an object of knowledge is combined with ideas about man as an end in itself, as self-sufficient, and about (...) man's freedom, his ability to set goals in general. Crudely put, for Kant ethics is primary, it "anticipates" direct knowledge. (shrink)

В монографии в широком историческом контексте охарактеризован процесс возникновения и развития сущностного наполнения принципа природосообразности в истории филисофско-педагогической мысли от античного периода по Новое время.

Vladimir Aleksandrovich Smirnov was born on March 2, 1931. He graduated from Moscow State University in 1954. From 1957 till 1961 he was a lecturer in philosophy and logic at the Tomsk University. Since 1961 his scientific activity continued in Moscow at the Institute of Philosophy of Academy of Sciences of the USSR. From 1970 and till the last days of his life V. A. Smirnov was lecturer and then Professor at the Chair of Logic at Moscow State University. V. (...) A. Smirnov played an important role at the Institute of Philosophy of Russian Academy of Sciences being the Head of Department of Epistemology, Logic and Philosophy of Science and Technology, and the Head of Section of Logic. Last years he was the leader of the Centre of Logical Investigations of Russsian Academy of Sciences. In 1990-91 he founded a new non-goverment Institute of Logic, Cognitive Sciences and Development of Personality for performing research, teaching, editorial and organization activity in the field of humanities. At the Department of Philosophy of Moscow State University and at the Institute of Philosophy V. A. Smirnov and his close colleagues have founded a Russian logical school which brought up many talented researchers who work at several scientific centres in various countries. (shrink)

A compact edition of Mr. Beck's excellent translation of the second Critique, slightly revised, together with a helpful short introduction and a bibliography.--V. C. C.